ea0011p247 | Cytokines and growth factors | ECE2006
Catrina SB
, Botusan IR
, Rantanen A
, Catrina AI
, Pyakurel P
, Axelson M
, Biberfeld P
, Poellinger L
, Brismar K
Neoangiogenesis is essential for tumor development. Hypoxia inducible factor (HIF), a transcriptional factor composed of two subunits (α and β) plays a key role in this process, activating proangiogenic factors, such as VEGF. The HIF α subunits are critically regulated by oxygen but also modulated by growth factors. Kaposi Sarcoma (KS) is a highly vascular tumor which releases large amounts of VEGF and for which we have recently described an essential role for I...